How Does Excellagen Formulated Collagen Work?

Collagen is the main component of connective tissue and is the most abundant protein in mammals.  In humans, it comprises approximately 30% of the protein found in the body.  Due to its unique characteristics and diverse profile in human body functions, collagen is frequently selected from a variety of bio-compatible materials for use in tissue repair to support structural integrity, induce cellular infiltration and promote healing.

 

Type I collagen is the most abundant form of collagen in the human body.  It is the dominant constituent of connective tissue and serves as the primary scaffold in tissue or organ repair processes, making it a logical choice for regenerative medicine products.  It is found in tendons, ligaments, skin, artery walls, corneas, the endomysium surrounding muscle fibers, fibrocartilage, and the organic part of bones and teeth. 

 

Excellagen® uses bovine collagen sourced only from Australia and New Zealand and uses the skin to produce the product.  This product is refined and purified using an organic process and because of its purification shows unique and outstanding healing characteristics with a fully functional 3-D matrix of extremely thin fibers (up to 100x finer than competing products) which leads to fast cell proliferation and expedites tissue granulation, re-epithelization and ultimately complete wound repair even in difficult to heal wounds.

 Magnification: 6500X

Magnification: 6500X

 Magnification: 21,000X

Magnification: 21,000X

Endogenous Collagen Assembly

 Endogenous Collagen Assembly

Endogenous Collagen Assembly


Collagen is essential for every phase of wound healing

 

Excellagen is a highly purified formulated homogenate of fibrillar bovine Type I collagen.

Excellagen's 3-dimensional fibrillar structure functions as a dermal scaffold, promoting chemotaxis, cellular adhesion, migration and proliferation to stimulate granulation tissue formation.

  • Highly controlled manufacturing process generates high molecular weight fibrillar form of collagen.

  • Formulated in a specialized physiologic buffer that provides protein stabilization with maintenance of Excellagen's key structural and functional properties.

 Electron Microscope Image of Excellagen Fibrillar Collagen

Electron Microscope Image of Excellagen Fibrillar Collagen


The Excellagen Competitive Advantage

 Excellagen is a pharmaceutically formulated, bovine dermal atelo-collagen homogenate in a 3-D staggered array (fibrillar collagen) dermal matrix.

Excellagen is a pharmaceutically formulated, bovine dermal atelo-collagen homogenate in a 3-D staggered array (fibrillar collagen) dermal matrix.

 

Excellagen® is a topically applied, syringe-based dermal matrix that functions to activate platelets, triggering release of key wound healing platelet-derived growth factors, and as a structural matrix for cellular migration and proliferation. It is an aseptically manufactured, pharmaceutically-formulated 2.6% fibrillar Type I bovine collagen gel that is configured into a staggered quaternary array of three-dimensional triple helical, telopeptide-deleted tropocollagen molecules. These linear arrays form a flowable, biocompatible and bioactive structural matrix that to promote chemotaxis, cellular adhesion, migration and proliferation to stimulate granulation tissue formation.

Other marketed collagen-based products typically do not undergo the same degree of purification that Excellagen is subjected to, contain non-collagenous tissue components, are lyophilized or hydrolyzed and presented in a sheet configuration or a ground up powder requiring hydration before use. Excellagen’s ready-to use 2.6% formulated collagen gel allows for: 

  • Easy application to tunneling wounds via syringe with flexible applicator tip conforms to the shape of the wound and fills deep, tunnel-like wounds and or wide surface

  • Versatile, highly flowable, adherent gel formulation and the sterile, single use syringe applicator and tip allow for easy application, complete coverage, and intimate contact with wounds of varied etiology, shape, size, depth and surface contour

  • Immediately upon contact with a small amount of blood induces repopulation of PDGF the key mediator in wound healing, other growth factor and revascularization of tissue

  • greater versatility and ease of use than fix-structured, sheet-based products that require cutting to size, fixation to the wound by suturing or stapling

  • Requires no product thawing or reconstitution before use. Furthermore, there is no product trimming or suturing required during application of Excellagen 

  • May minimize the need for more extensive surgical intervention such as Grafts

  • Replaces damaged or missing tissue with 'like' tissue 

 

 

Excellagen Product Processing

 
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Excellagen is an aseptically manufactured, flowable dermal matrix consisting of a stabilized formulation of renatured atelopeptide bovine fibrillar tropocollagen supplied in prefilled, ready to use syringes. Excellagen is manufactured according to Current Good Manufacturing Practices (cGMP) and requires controlled temperature storage (2-8°C/34-38°F) to maintain structural integrity and bioactivity. Excellagen has a shelf life of approximately 3 years.

During manufacture, the collagen component of Excellagen is purified using a specialized, validated aseptic process that effectively inactivates potential contaminating viruses, eliminates impurities, and removes denatured molecules and collagen fragments. Excellagen consists almost exclusively of high molecular weight, intact, fibrillar collagen and is formulated at a concentration of 2.6% (26 mg/mL) in a physiologic buffer with protein stabilizing agents.

Excellagen uses bovine collagen sourced only from Australia and New Zealand and uses the skin to produce the product.This product is refined and purified using an organic process and because of its purification shows unique and outstanding healing characteristics with a fully functional 3-D matrix of extremely thin fibers (up to 100x finer than competing products) which leads to fast cell proliferation and expedites tissue granulation, re-epithelization and ultimately complete wound repair in even difficult to heal wounds.

 

U.S. PATENT

 

On October 10, 2017, Excellagen was granted an Intellectual Property Patent (2013/0096064A1) “Flowable Formulations for Tissue Repair” based on the following attributes:

  • A method to repair a wound by promoting PDGF release by platelets by entering by an in-situ microstructural matrix

  • A permeable microstructural fibular matrix to act as an in-situ scaffold for migration of cells by administering a formulation comprising renatured atelopeptide tropocollagen

  • The wound is selected from a group consisting of a traumatic injury wound, a diseased state, an iatrogenic wound, a soft tissue wound a chronic wound and a combination thereof

  • The formulation further comprises a wound-healing agent