How Does Excellagen Formulated Collagen Work?
Collagen is the main component of connective tissue and is the most abundant protein in mammals. In humans, it comprises approximately 30% of the protein found in the body. Due to its unique characteristics and diverse profile in human body functions, collagen is frequently selected from a variety of bio-compatible materials for use in tissue repair to support structural integrity, induce cellular infiltration and promote healing.
Type I collagen is the most abundant form of collagen in the human body. It is the dominant constituent of connective tissue and serves as the primary scaffold in tissue or organ repair processes, making it a logical choice for regenerative medicine products. It is found in tendons, ligaments, skin, artery walls, corneas, the endomysium surrounding muscle fibers, fibrocartilage, and the organic part of bones and teeth.
Excellagen® uses bovine collagen sourced only from Australia and New Zealand and uses the skin to produce the product. This product is refined and purified using an organic process and because of its purification shows unique and outstanding healing characteristics with a fully functional 3-D matrix of extremely thin fibers (up to 100x finer than competing products) which leads to fast cell proliferation and expedites tissue granulation, re-epithelization and ultimately complete wound repair even in difficult to heal wounds.
Endogenous Collagen Assembly
Collagen is essential for every phase of wound healing
Excellagen is a highly purified formulated homogenate of fibrillar bovine Type I collagen.
Excellagen's 3-dimensional fibrillar structure functions as a dermal scaffold, promoting chemotaxis, cellular adhesion, migration and proliferation to stimulate granulation tissue formation.
Highly controlled manufacturing process generates high molecular weight fibrillar form of collagen.
Formulated in a specialized physiologic buffer that provides protein stabilization with maintenance of Excellagen's key structural and functional properties.
The Excellagen Competitive Advantage
Excellagen® is a topically applied, syringe-based dermal matrix that functions to activate platelets, triggering release of key wound healing platelet-derived growth factors, and as a structural matrix for cellular migration and proliferation. It is an aseptically manufactured, pharmaceutically-formulated 2.6% fibrillar Type I bovine collagen gel that is configured into a staggered quaternary array of three-dimensional triple helical, telopeptide-deleted tropocollagen molecules. These linear arrays form a flowable, biocompatible and bioactive structural matrix that function to promote chemotaxis, cellular adhesion, migration and proliferation to stimulate granulation tissue formation.
Other marketed collagen-based products typically do not undergo the same degree of purification that Excellagen is subjected to, contain non-collagenous tissue components, are lyophilized or hydrolyzed and presented in a sheet configuration or a ground up powder requiring hydration before use. Excellagen’s ready-to use 2.6% formulated collagen gel allows for:
Easy application to tunneling wounds via syringe, with a flexible applicator tip that conforms to the shape of the wound and fills deep, tunnel-like wounds and/or large surface areas
Versatile, highly flowable, adherent gel formulation and the sterile, single use syringe applicator and tip allow for easy application, complete coverage, and intimate contact with wounds of varied etiology, shape, size, depth and surface contour
Immediately upon contact with a small amount of blood induces repopulation of PDGF (the key mediator in wound healing), other growth factors and revascularization of tissue
greater versatility and ease of use than fix-structured, sheet-based products that require cutting to size, fixation to the wound by suturing or stapling
Requires no product thawing or reconstitution before use. Furthermore, there is no product trimming or suturing required during application of Excellagen
May minimize the need for more extensive surgical intervention such as grafts
Replaces damaged or missing tissue with 'like' tissue
Excellagen Product Processing
Excellagen is an aseptically manufactured, flowable dermal matrix consisting of a stabilized formulation of renatured atelopeptide bovine fibrillar tropocollagen supplied in prefilled, ready to use syringes. Excellagen is manufactured according to Current Good Manufacturing Practices (cGMP) and requires controlled temperature storage (2-8°C/34-38°F) to maintain structural integrity and bioactivity. Excellagen has a shelf life of approximately 3 years.
During manufacture, the collagen component of Excellagen is purified using a specialized, validated aseptic process that effectively inactivates potential contaminating viruses, eliminates impurities, and removes denatured molecules and collagen fragments. Excellagen consists almost exclusively of high molecular weight, intact, fibrillar collagen and is formulated at a concentration of 2.6% (26 mg/mL) in a physiologic buffer with protein stabilizing agents.
Excellagen uses bovine collagen sourced only from Australia and New Zealand and uses the skin to produce the product.This product is refined and purified using an organic process and because of its purification shows unique and outstanding healing characteristics with a fully functional 3-D matrix of extremely thin fibers (up to 100x finer than competing products) which leads to fast cell proliferation and expedites tissue granulation, re-epithelization and ultimately complete wound repair in even difficult to heal wounds.
On October 10, 2017, Excellagen was granted an Intellectual Property Patent (2013/0096064A1) “Flowable Formulations for Tissue Repair” based on the following attributes:
A method to repair a wound by promoting PDGF release by platelets by entering by an in-situ microstructural matrix
A permeable microstructural fibular matrix to act as an in-situ scaffold for migration of cells by administering a formulation comprising renatured atelopeptide tropocollagen
The wound is selected from a group consisting of a traumatic injury wound, a diseased state, an iatrogenic wound, a soft tissue wound a chronic wound and a combination thereof
The formulation further comprises a wound-healing agent