How To Use

In accordance with the FDA-cleared instructions for use, Excellagen is applied topically to a chronic dermal or acute wound immediately following surgical debridement, a standard practice used by medical professionals to remove necrotic tissue, resulting in a bleeding wound bed. As covered in the U.S. patent, the application of Excellagen following debridement, in the presence of a small amount of blood, promotes platelet activation and endogenous release of key wound healing growth factors, including platelet derived growth factor-BB (PDGF-BB).

  • Off the shelf, ready to use
  • Pre-filled, single-use syringes containing 0.5cc of Excellagen flowable dermal matrix (in sterile packaging)
  • Supplied with sterile flexible applicator for easy access to deep tunneled wounds
  • Simple and ready to use: no thawing or reconstitution
  • Flowable: no staples or sutures
  • Viscosity optimized for complete, dripless wound coverage
  • Treatment at once weekly intervals
  • One syringe (0.5 cc) covers up to 5.0 cm2 wound
  • Refrigerated 35-46°F (2-8°C) storage required
  • For professional use only

Instructions For Use


1.  Perform sharp debridement of the wound bed to ensure that wound is free of debris and necrotic tissue. Allow a small influx of blood into the wound before applying Excellagen.

2.  Spread Excellagen onto the entire wound surface, including the edges. For tunneled/undermined wounds, first determine the base of the wound bed utilizing the flexible applicator tip, and then fill the tissue voids.

3.  After application, overlay with a non-adherent dressing to maintain product adherence and to protect the wound area. Additional layers of gauze or foam dressings may be applied on top of the non-adherent dressing to manage exudate. Secure with outer stretch bandage.

4.  Offload using a specialized shoe or boot

5.  If the wound is not completely healed, Excellagen may be reapplied once per week.

* Patients are not required to do any home care after Excellagen has been applied to the wound and is dressed, relieving patients and caregivers of any burden-of-care. Patients may chose to change the non-adherent dressing at home.


Wound Therapy


When applied following debridement, or to healthy wound beds devoid of necrotic tissue and debris, Excellagen’s flowable format allows intimate contact of the fibrillar collagen with the entire wound surface, including wound edges and surface contours/irregularities, even in tunneling/undermined wounds. A non-adherent dressing is placed over Excellagen. The fibrillar collagen becomes functionally integrated into the wound, providing chemotactic signals for repair cells, including inflammatory cells and fibroblasts, and a biocompatible/bioresorbable structural scaffold for cellular adhesion, migration and proliferation (Brett, 2008; Li et al., 2004; Purna and Babu, 2000; Rangaraj et al., 2011). Foam dressings are designed to provide exudate absorption and wound protection. They are truly temporary surface products, that do not provide any of the structural and functional benefits of collagen-based dressings